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A research group led by Hidetoshi Akutsu of the Department of Reproductive Medicine at the National Center for Research and Development (NCRD), which affiliates to Center Hospital of the National Center for Global Health and Medicine (NCGM), verified the differences in infectivity, proliferation, and transmission efficiency of mutant strains of COVID-19 in intestinal tissues using a three-dimensional organ of the intestinal tract derived from human iPS cells.

Image Source: wikipedia

After validation, it was found that the Delta variant is significantly more proliferative in the intestinal tube epithelium, causing concomitant cell injury, and secretion of inflammatory cytokines (cytokines). On the other hand, BA.1 and BA.2 of Omicron have extremely low infection and proliferation efficiency in intestinal tissue, and almost no increase in cell damage and inflammation-related factors.

The changes in infectivity and proliferation of each viral variant in tissues and organs reflect the phenomenon of infection in humans and can be expected to contribute to the understanding of the pathology of the now prevalent Omicron variant. The findings were published in Gastroenterology (online), the journal of the American Society of Gastrointestinal Diseases.

Image Source: PAHO

Reference:
https://gnews.org/post/p2581820/

Edited by:  MikeHua
Posted by: Peter Chen

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