作者:加拿大溫哥華揚帆農場Michael.Tonny

在筆者過去的文章中,有接近幾十篇討論注射中共病毒疫苗既不能減少感染,也不能減少死亡,注射這種毒疫苗會帶來嚴重副作用等話題。然而,僅僅暴露於COVID-19疫苗揮發的環境中,都會遇到嚴重的問題,過去從未涉及。

然而,泰國曼谷Rajavithi醫院在2020年4月就發生了這種匪夷所思的事件!

2020年4月,Rajavithi醫院在接種來自于中共國北京科興控股生物技術有限公司的CoronaVac疫苗時,一名護士不小心摔碎了一小瓶0.5毫升的疫苗,結果導致15名工作人員出現眼表糜爛(ocular surface erosion)。北京科興控股生物技術有限公司宣稱,科興疫苗是由β-丙內酯滅活SARS-CoV-2病毒顆粒(beta-propiolactone inactivated SARS-CoV-2 virus particles)溶於氫氧化鋁溶液製成的疫苗。

本文摘自2020年10月6日,泰國曼谷Rangsit大學醫學院Rajavithi醫院眼科(Department of Ophthalmology)Somporn Chantra、Pareena Chaitanuwong、Seresirikachorm K、Paisan Ruamviboonsuk,皮膚科(Department of Dermatology)Brinks M、Chamberlain W和美國俄勒岡州波特蘭市俄勒岡健康與科學大學(Oregon Health & Science University)凱西眼科研究所(Casey Eye Institute)Brinks M等人發表的論文Ocular Surface Erosion after Suspected Exposure to Evaporated COVID-19 Vaccine

疫苗接種區是一個封閉的空間,其中一部分被分為6個大小相等的小房間,前後走廊相互連接,1-4號房間用於接種疫苗,5-6號房間用於登記。所有房間都有一個正常運行的空調系統,沒有額外的通風裝置或空氣過濾裝置。

被分隔的區域長11.04米,深5.96米,高2.6米。分隔後的6個小房間高2.5米,寬 1.84米。前後走廊分別為11.04米×1.67米和11.04米×1.79米,後走廊有一個11.04米×0.6 m的洗滌區。每面牆的頂部有一個 0.6 m的露天空間。紅色飛濺表示疫苗意外掉落的位置。

The purpose is to report ocular surface erosion of health personnel who were exposed to evaporated CoronaVac during a vaccination campaign. A campaign for CoronaVac vaccination was conducted in a closed space of 11.04 × 5.96 m, partially divided into 6 rooms with interconnected area among the rooms. A total of 20 health personnel worked in the vaccination rooms. On the third day of campaign, a vial, containing a single dose of 0.5 mL, of the vaccine was dropped accidentally onto the floor and broken by an administering nurse. A total of 15 personnel had symptoms and signs of ocular surface erosion at the average time from the accident to the onset of 10.2 ± 7.1 h; 4 personnel also had skin rash. These personnel included all 13 persons who already worked in the rooms when the accident occurred and continued for additional 4–6 h and 2 personnel who presented in the rooms 1–2 h after the accident and stayed for 2–3 h. Proximity and timing suggest CoronaVac correlation with the ocular and skin reactions. Cautions should be taken to avoid broken vials, spills, and aerosolization of CoronaVac during the vaccination.

前兩天一切正常,第三天,共有20名工作人員正在工作,護士準備和接種疫苗,其他人是助理,除口罩外,都沒有使用其它任何防護設備。4號房間的一名護士不小心摔碎了一小瓶0.5毫升的疫苗,導致其溢出到3號和4號房間之間靠近牆壁的地板上。她立即用一張紙巾擦拭乾淨並將紙巾丟棄在4號房間的垃圾箱中,並在那裡放置了一整天。

共有15名工作人員出現眼部症狀,這15名工作人員包括事故發生時正在房間內工作,之後又繼續工作4~6小時的13人和事故發生後才開始工作了3小時的2人。事故發生後在房間內只工作了半小時的其他5人員沒有任何症狀。

從事故到出現症狀的平均時間為10.2±7.1小時。症狀是眼睛刺激(eye irritation,60%)、眼睛發紅(red eyes,50%)、流淚(tearing,45%)、眼瞼腫脹(swollen eyelids ,30%)和皮疹(skin rash,20%)。

15名出現眼部症狀的人員均出現一定程度的無乳突或濾泡(papillae or follicles)結膜炎(conjunctivitis),根據牛津分級系統(Oxford Grading System),眼瞼間區域(interpalpebral area)螢光素染色呈陽性(positive fluorescein staining),為點狀上皮糜爛(punctate epithelial erosion),嚴重程度為1至3級。未受影響人員的眼科檢查無異常。

The purpose is to report ocular surface erosion of health personnel who were exposed to evaporated CoronaVac during a vaccination campaign. A campaign for CoronaVac vaccination was conducted in a closed space of 11.04 × 5.96 m, partially divided into 6 rooms with interconnected area among the rooms. A total of 20 health personnel worked in the vaccination rooms. On the third day of campaign, a vial, containing a single dose of 0.5 mL, of the vaccine was dropped accidentally onto the floor and broken by an administering nurse. A total of 15 personnel had symptoms and signs of ocular surface erosion at the average time from the accident to the onset of 10.2 ± 7.1 h; 4 personnel also had skin rash. These personnel included all 13 persons who already worked in the rooms when the accident occurred and continued for additional 4–6 h and 2 personnel who presented in the rooms 1–2 h after the accident and stayed for 2–3 h. Proximity and timing suggest CoronaVac correlation with the ocular and skin reactions. Cautions should be taken to avoid broken vials, spills, and aerosolization of CoronaVac during the vaccination.

在4號房間不小心摔碎疫苗的護士和在3號房間戴隱形眼鏡工作的助理出現了最嚴重、最長的臨床表現,在接受了3天的局部氟米龍QID(topical fluorometholone QID)後,持續了2周。其餘受影響的人員使用了局部抗組胺藥(topical antihistamine)或潤滑劑。46.7%的人在72小時內完全恢復,在最後一次檢查中均顯示完全恢復。所有人員逆轉錄聚合酶鏈反應(reversetranscriptionpolymerasechainreaction,或PCR)測試結果均為陰性。

591名疫苗接種者和在接種區附近但不在接種區工作的醫院工作人員均未報告類似症狀。此外,此前2天出現在同一區域的1,705名疫苗接種者和其它36名工作人員沒有出現任何症狀。說明這15名工作人員的症狀完全由摔碎的疫苗揮發引起的。

疫苗接種空間的總體積為287.61m3,洩漏疫苗的體積僅0.5mL,如此小劑量的揮發都會導致如此嚴重的後果!

參考資料:

科興疫苗:新型冠狀病毒滅活疫苗-克爾來福®

Ocular Surface Erosion after Suspected Exposure to Evaporated COVID-19 Vaccine

編輯:Michael.Tonny上傳:Michael.Tonny