By 22rOn 

Published June 18, 2021

The purpose of this series is to explain the connections between the Chinese Communist Party’s virology research programs since 2005 and the research institutions involved, including those in Hong Kong. All information is sourced from the Internet. The analysis and conclusions presented here reflect author’s own views only.

Below is an excerpt from the original report Disclosure Report on CCP’s Virus Research Programs and Projects, edited to fit for online publishing.

In this series, we examine the blueprint of the CCP’s virus research program by focusing on the research program titled Research on Cross-Species Infection and Transmission Mechanism of Major Outbreak of Human-Animal Infections with Animal Origin (hereinafter referred to as the 2016 Virus Program).

With all the information presented in the previous articles, we now conclude this series with a summary, and present the supporting materials.

Conclusion

The CCP has been conducting systematic, organized, and opportunistic virus research for quite a long time. Behind the creation of Covid-19 is the CCP’s virus research program on zoonotic diseases. One example of such research program is the 2016 Virus Program. This program is an extension of director of China CDC, Mr. GAO Fu’s 2005-2015 research project named “Research Project on Mechanisms of Interspecies Infection and Transmission of Viruses of Animal Origin” and “Research Project on Molecular Mechanisms of Pathogenesis of Interspecies Infection and Transmission of Important Viruses”. Wuhan Institute of Virology and PLA’s military medical research institutions are directly involved in these projects. The personnel and funding involved are complex and large, including several military-grade research projects, US NIH, Bill and Melinda Gates Foundation, among other investment agencies. The evidence provided in this report strongly suggests that the CCP’s military is highly likely to have been conducting military-grade biological weapons research at the Wuhan Institute of Virology.

Secondly, in addition to the Wuhan Institute of Virology, it is possible that the CCP authorities have also conducted virus research in other research institutions at the same time. According to the investigation on HKU’s Malik Peiris and GUAN Yi, the CCP very likely has conducted the virus research in Hong Kong and Guangdong, through Shantou University, the newly established Joint Virology Institute of Shantou University and HKU, and the cooperation of Malik Peiris and ZHAO Jincun of Guanzhou Medical University. 

COVID-19 may have revealed just a tip of an iceberg of the CCP authorities’ virus research program. According to our investigation, the CCP has various programs under various names, such as the Program 973, the “Infectious Disease Prevention and Control” of National Science and Technology Major Program, to conduct vast, complex and covert national-level virology research programs in a massive and concerted manner, in the course of weaponizing various viruses including Zika, bird flu, Ebola, Dengue, West Nile, and Chikungunya virus. They have conducted large-scale and long-term research on virus analysis and identification, virus transmission and evolution, virus-host interactions, and effective antiviral drugs development studies. Based on the information from our current investigation, the CCP has done the most detailed research on Zika virus and bird flu virus, and those researches have yielded the most results for the CCP authorities. This indicates that the CCP may have altered and weaponized these two viruses, which poses a great risk to the life, health and safety of all mankind.

The CCP has a 20+ year plan to dominate the world. It is being carried out in the name of “One World, One Health” using national-level planning. By following the “Military-Civil Fusion” strategy, CCP scatters its bio-weapon research efforts all across the country to support its CCP virus creation, which is funded by national and local and overseas enterprises and institutions.

If we don’t immediately hold the CCP authorities accountable for their role in the Covid-19 pandemic, it is very likely that more types of man-made deadly virus will imperil mankind again, endlessly wreaking havoc and eroding the entire human civilization.

Annex I 2016 Virus Project Participant List

This table was generated by searching key participants and corresponding authors in the relevant literature, and does not represent a complete list of all personnel. For reference only.

Project numberProject nameSubject participantsAffiliated units
2016YFD0500300Research on Cross-Species Infection and Transmission Mechanism of Major Outbreak of Human-Animal Infections with Animal Origin (parent subject)Wenjie Tan1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Yusen Zhou7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Zhendong Zhao4. Institute of Pathogen Biology, Chinese Academy of Medical Sciences
   Yi SHI1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Fu GAOChinese Center for Disease Control and Prevention
 Hao SONGBeijing Institute of Life Sciences, Chinese Academy of Sciences
 Sheng CUI4. Institute of Pathogen Biology, Chinese Academy of Medical Sciences
 Lilin Zhao2. Institute of Zoology, Chinese Academy of Sciences
 Jianghua Sun2. Institute of Zoology, Chinese Academy of Sciences
 Guimei HeEast China Normal University
 Aihua ZhengWuhan Institute of Virology, Chinese Academy of Sciences
 Xiaoqing LuQingdao University
 Guodong Liang1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Hongxuan He2. Institute of Zoology, Chinese Academy of Sciences
 Yousong Peng17. Hunan University
 Aiping Wu9. Suzhou Institute of Systemic Medicine, Chinese Academy of Medical Sciences
 Leiliang ZhangShandong First Medical University (Institute of Pathogen Biology, Chinese Academy of Medical Sciences)
 Yuelong Shu1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Dayan WangChinese Center for Disease Control and Prevention
 Taijiao Jiang9. Suzhou Institute of Systemic Medicine, Chinese Academy of Medical Sciences
 Haitao Yang15. Tianjin University
 Xiaoyun Ji14. Changzhou Nanjing University High-Tech Research Institute
 Min FANG3. Institute of Microbiology, Chinese Academy of Sciences
 Zhongyang Tan17. Hunan University
 YouyangKePLA 171 Hospital
 Zhe WANG12. Shenyang Agricultural University
 Shuyi Zhang12. Shenyang Agricultural University
 Langfeng WangShanghai Pasteur Institute, Chinese Academy of Sciences
 Zefang Wang15. Tianjin University
 Houwen Tian1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Li RUAN1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 PeihuaNiu1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Xiaoling ShenInner Mongolia Medical University
  Jian PENG16. Central South University (Xiangya Hospital)
  Jun ZHAOUniversity of Southern California, USA
  Xia Zanxian16. Central South University (Xiangya Hospital)
  Liao Qiande16. Central South University (Xiangya Hospital)
2016YFD0500301Rapid identification, traceability and early warning of major human-animal disease outbreaks and interdiction strategiesWenjie Tan1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Fu GAOChinese Center for Disease Control and Prevention
 Jincun ZhaoGuangzhou Medical University
 Chuan QIN2. Institute of Zoology, Chinese Academy of Sciences
 Songdong Meng3. Institute of Microbiology, Chinese Academy of Sciences
 Jianxun Qi3. Institute of Microbiology, Chinese Academy of Sciences
 Shixing TangSouthern Medical University
 Xiaoling ShenInner Mongolia Medical University
 Yuelong Shu1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Dayan WangChinese Center for Disease Control and Prevention
2016YFD0500302Study on the animal origin, evolution and transmission of MERS coronavirusYi GUANUniversity of Hong Kong
 Yi GUAN(same)10. Shantou University
 Hana M. El SahlyBaylor College of Medicine, USA
 Guangchuang YuSouthern Medical University
2016YFD0500303Study on the natural epidemiological origin and transmission circle of West Nile virus and Chikungunya virusJinglin Wang8. Yunnan Academy of Animal Husbandry and Veterinary Science
 何宏轩 Hongxuan He2. Institute of Zoology, Chinese Academy of Sciences
 Chang YungfuCornell University, USA
 Aihua ZhengWuhan Institute of Virology, Chinese Academy of Sciences
 Fei YUAN3. Institute of Microbiology, Chinese Academy of Sciences
 Dexin Li1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 ChangwenKeGuangdong Center for Disease Control and Prevention
 Mifang Liang1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
2016YFD0500304Experimental models of pathogen infection and transmission and studies of adaptive evolution and pathogenicity, hostophiliaLu LUFudan University
 Shibo JiangFudan University
 Chengfeng Jiang7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Guoyong YuanUniversity of Hong Kong
 Lanying DuNew York Blood Center
 Peiyong ShiUniversity of Texas, USA
 Xiangxi WangInstitute of Biophysics, Chinese Academy of Sciences
 Yongqiang Deng7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Zhiheng XuInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences
 Xiaofeng Li7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Ruikang TangZhejiang University
 Genhong Cheng9. Suzhou Institute of Systemic Medicine, Chinese Academy of Medical Sciences
 Xiaofeng Qin9. Suzhou Institute of Systemic Medicine, Chinese Academy of Medical Sciences
 Chuan QIN2. Institute of Zoology, Chinese Academy of Sciences
 Linlin Bao2. Institute of Zoology, Chinese Academy of Sciences
 Xianyang Fang11. Tsinghua University
 Zihe Rao11. Tsinghua University
 David I. StuartUniversity of Oxford
 Jianghong ManNational Center for Biomedical Analysis
 Bo ZHANGWuhan Institute of Virology, Chinese Academy of Sciences
 Leiliang ZhangShandong First Medical University (Institute of Pathogen Biology, Chinese Academy of Medical Sciences)
 Wenjie Tan1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Chuan QIN2. Institute of Zoology, Chinese Academy of Sciences
 Songdong Meng3. Institute of Microbiology, Chinese Academy of Sciences
 Jincun ZhaoGuangzhou Medical University
2016YFD0500305Important protein structural analysis for pathogen-host interactionsFu GAOChinese Center for Disease Control and Prevention
 Jianxun Qi3. Institute of Microbiology, Chinese Academy of Sciences
 Feng GAOTianjin Industrial Biotechnology Research Institute
 Wenjie Tan1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention
 Chuan QIN2. Institute of Zoology, Chinese Academy of Sciences
 Songdong Meng3. Institute of Microbiology, Chinese Academy of Sciences
 Jincun ZhaoGuangzhou Medical University
 Jinhai Huang15. Tianjin University
2016YFD0500306Study on the evolutionary development of immunity and immune recognition characteristics of different species of animals against pathogensYusen Zhou7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Shibo JiangFudan University
 Lanying DuNew York Blood Center
 Fang LIUniversity of Minnesota, USA
 Enqi Du13. Northwest Agriculture and Forestry University
 Suresh K. TikooUniversity of Saskatchewan, Canada
 Xiaoying Zhang13. Northwest Agriculture and Forestry University
 Linqi Zhang11. Tsinghua University
 Xinquan Wang11. Tsinghua University
 Sha PENG13. Northwest Agriculture and Forestry University
 Jinlian Hua13. Northwest Agriculture and Forestry University
2016YFD0500307Mechanisms of important pathogen-host immune system interactions and cross-species transmissionShan CEN6. Institute of Pharmaceutical Biotechnology, Chinese Academy of Medical Sciences
 Xiaoyu Li6. Institute of Pharmaceutical Biotechnology, Chinese Academy of Medical Sciences
 Mei GEShanghai Jiao Tong University
 Yusen Zhou7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Shibo JiangFudan University
 Lanying DuNew York Blood Center
 Shihui Sun7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences(Institute of Biological Engineering, PLA Academy of Military Medical Sciences)
 Guangyu Zhao7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Yan GUO7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Yuehong Chen7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Junfeng Li7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Xinquan Wang11. Tsinghua University
 Ye XIANG11. Tsinghua University
 Chen LIANGMcGill University, Canada
 Chengfeng Qin7. Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
 Fei GUO6. Institute of Pharmaceutical Biotechnology, Chinese Academy of Medical Sciences
 Linqi Zhang11. Tsinghua University
 Xinquan Wang11. Tsinghua University
 Baoluo ZhouShanghai Pasteur Institute, Chinese Academy of Sciences
 Mifang Liang1. Institute of Viral Disease Prevention and Control, Chinese Center for Disease Control and Prevention

Annex II Funding Information of the 2016 Virus Program

This table is a summary of search results, which include all the projects and funding information of the 2016 Virus Program by December 2019. The Chinese name of some researchers could not be found.

2016 Virus Program/Project No.Paper TitlePublication Date (online) Year/MonthAuthorsOther Funding SupportNote
2016YFD0500300Homologous recombination shapes the genetic diversity of African swineAugust, 2019Zhaozhong Zhu, Chao-Ting Xiao, Yunshi Fan, Zena Cai, Congyu Lu, Gaihua Zhang, Taijiao Jiang, Yongjun Tan, Yousong Peng*The National Key Technology R&D Program of China (2017YFD0500104), National Natural Science Foundation of China (31671371), Chinese Academy of Medical Sciences (CAMS) Innovation Fund (2016-12M-1-005),  Natural Science Foundation of Hunan Province (2018JJ3039)
2016YFD0500300Analysis of Microsatellite Distribution in Complete Ebolavirus GenomesMarch, 2019Siqian Zhou, Weili Jiao, Zhuli Peng, Jingyu Zhou, Xingxin He, Durui Li, Mingfu Li, Zhongyang Tan*The National Key Technology R&D Program of China (2016YFC1200200), Research and application of inspection and control technology for massive cross-border biological species  (2017YFF0210300), Big data platform and assessment and early warning system for massive cross-border species (2017YFF0210301)
2016YFD0500300The biological function of guanylate binding protein 2May, 2019Jinhong Tang, Haitao Yang, Zefang Wang*973 Program (2014CB542800, 2015CB859800), National Natural Science Foundation of China (31528006)
2016YFD0500300A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible miceJuly, 2018PeihuaNiu, Guangyu Zhao, Yao Deng, Shihui Sun, Wenling Wang, Yusen Zhou*, Wenjie Tan*Wenjie Tan and L. Haagmans and Ron A.M. of Erasmus MC in Rotterdam, Zuid-Holland also contributed to this work.
2016YFD0500300Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structureAugust, 2016Xiaoying Xu, Hao Song, Jianxun Qi, Yuqian Liu, Haiyuan Wang, Chao Su, Yi SI*, Fu GAO*China Ministry of Science and Technology National 973 Project Grant (2014CB542503), National Natural Science Foundation of China (81641001, 81622031), the Emergency Task-Force Project of Zika Virus Research, The Strategic Priority Research Program of the Chinese Academy of Sciences (XDB08020100), Chinese Academy of Sciences (CAS) Youth Innovation Promotion Association (2015078)Partially funded by the National Natural Science Foundation of China Innovation Research Group 81321063, led by Fu Gao.
2016YFD0500300Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virusNovember, 2017Haiyuan Wang, Min Han, Jianxun Qi, Rolf Hilgenfeld, Tingrong Luo, Yi Shi, Fu GAO*, Hao Song*National Science and Technology Major Project (2017ZX10303403), National Natural Science Foundation of China (2016QNRC001), Chinese Academy of Sciences (CAS) Youth Innovation Promotion Association 2015078 and (2017117).Partially funded by the National Natural Science Foundation of China Innovation Research Group 81621091, led by Fu Gao.
2016YFD0500300From discovery to spread: The evolution and phylogeny of Getah virusNovember, 2017Yuan-Yuan Li, Hong Liu, Shihong Fu, Xiaolong Li, Xiaofang Guo, Minghua Li, Yun Feng, Wei-Xin Chen, Li-Hua Wang, Wenwen Lei, Xiaoyan Gao, ZhiLyu, Ying He, Huanyu Wang, Hongning Zhou, Gui-Qin Wang*  Guodong Liang*The National Key Research and Development Program of China (2016YFC120190), State Key Laboratory of Infectious Disease Prevention and Control (SKLID) (2014SKLID103, 2015SKLID505), The Open Research Fund Program of the Chinese Academy of Sciences Wuhan National Biosafety Level-4 Laboratory (2017SPCAS003) 
2016YFD0500300Genome sequencing and phylogenetic analysis of Banna virus (genus Seadornavirus, family Reoviridae) isolated from CulicoidesOctober, 2017Song Song, Yuanyuan Li, Shihong Fu, Wenwen Lei, Xiaofang Guo, Yun Feng, Xiaoyan Gao, Xiaolong Li, Zhonghua Yang, Ziqian Xu, Ying He, Huanyu Wang, Hongning Zhou, Bin Wang, Xiaoqing Lu*, Guodong Liang*The National Key Research and Development Program of China (2016YFC1201904), National Natural Science Foundation of China (81290342, 81501757 [Special Science Fund]); State Key Laboratory of Infectious Disease Prevention and Control (2014SKLID103, 2015SKLID505).
2016YFD0500300Natural killer cells are activated and play a protective role against ZIKA virus infection in miceJuly, 2017Xuefeng Duan, Shihua Li, GaryWong, Dongfang Wang, Haoyu Wang, Jiao Lu, Yuhai Bia, Xuancheng Lu, Yi Shi, Jinghua Yan, Min Fang*, George Fu Gao*China Ministry of Science and Technology National 973 Project Grant (2015CB910503, 2014CB542602), National Natural Science Foundation of China (31370877, 31322020, 31400151), Emergency Task-Force Project of Zika Virus Research (KJZDEW-L15).Min Fang was supported by “The Recruitment Program of Global Experts”; Songji Wang was supported by the Banting Postdoctoral Fellowships of the Canadian Institutes of Health Research.
2016YFD0500300Significant Spike-Specific IgG and Neutralizing Antibodies in Mice Induced by a Novel Chimeric Virus-Like Particle Vaccine Candidate for Middle East Respiratory Syndrome CoronavirusOctober, 2018Jiaming Lan, Yao Deng, Kingdong Song, Baoying Huang, Wenling Wang, Wenjie Tan*Infectious Disease Control S&T Grand Project (2014ZX10004001-002, 2016ZX10004001-003), The National Key Research and Development Program of China (2016YFC1200901, 2016YFC1200200).Copyright belongs to Wuhan Institute of Virology
2016YFD0500300West Nile virus infection in suspected febrile typhoid cases in Xinjiang, ChinaJuly, 2017Lei Cao, Shihong Fu, ZhiLyu, Chengjun Tang, Shiheng Cui, Xiaolong Li, Xiaoyan Gao, Minghua Li, Yuxi Cao, Wenwen Lei, Ying He, HuanyuWang,  Guodong Liang*The National Key Research and Development Program of China (2016YFC1201900), National Natural Science Foundation of China (81290342, 81501757), State Key Laboratory of Infectious Disease Prevention and Control, SKLID, China CDC (2014
SKLID103,2015SKLID505)
2016YFD0500300ZIKA virus isolated from mosquitoes: a field and laboratory investigation in China, 2016October, 2017Shihong Fu, Song Song, Hong Li, Yuanyuan Li, Xiaolong Li, Xiaoyan Gao, Ziqian Xu, Guoping Liu, Dingming Wang, Zhenzhao Tian, Jingzhu Zhou, Ying He, Wenwen Lei, Huanyu Wang, Bing Wang, Xiaoqing Lu*, Guodong Liang*The National Key Research and Development Program of China (2016YFC1201904, 2017YFC1200202), National Natural Science Foundation of China (81290342, 81501757 [the Special National Project]), The Open Research Fund Program of the Chinese Academy of Sciences Wuhan National Biosafety Level-4  Laboratory (2017SPCAS003). The Chinese Academy of Sciences Wuhan National Biosafety Level-4 Laboratory was involved in this research
2016YFD0500300Preparation and characteristic analysis of six influenza A (H7N9) pseudovirus derived from different districts of ChinaAugust, 2017Baoying Huang, Shanqin Li, Xiangrong Qi, Jiao Ren, Jingdong Song, Wenjie Tan, Houwen Tian* & Li Ruan*National Infectious Disease Control S&T Grand Project (2014ZX10004002), 863 Program (2016AA02A203), National Natural Science Foundation of China (31200127), The National Key Research and Development Program of China (2016YFC1200200).
2016YFD0500300Performance evaluation of a novel automatic nucleic acid extraction method for detection of pathogensMay, 2019Liyuan Zhu, Wenjia Ye, Funa Lu, Jiaoxue Tang, Xiaokai Xia, PeihuaNiu, Wenjie Tan*The National Key Research and Development Program of China (2016YFC1200900).
2016YFD0500300Recent Advances in Novel Vaccines Development against Zika VirusNovember, 2017Ying Zhan, Yao Deng, Wenjie Tan*National Infectious Disease Control S&T Grand Project (2016ZX10004001-003).
2016YFD0500300Progress in development of neutralizing monoclonal antibody ( McAb ) against MERS-CoVSeptember, 2017Yingzhu Chen, Kun Qin, Wenjie Tan*The National Key Research and Development Program of China (2016YFC1200900), National Infectious Disease Control S&T Grand Project (2016ZX10004001-003).
2016YFD0500300Research progress in the serological detection of coronavirus(CoV)for the Middle East respiratory syndrome(MERS-CoV)May, 2018Miaomiao Ma, Xiaoling Shen, Wenjie Tan*The National Key Research and Development Program of China (2016YFC1200900), National Infectious Disease Control S&T Grand Project (2016ZX10004001-003).
2016YFD0500300Isolation and Identification of the Nam Dinh Virus from Mosquitoes on the China-Laos-Myanmar BorderNovember, 2016Wenwen Lei, Xiaofang Guo, Shihong Fu, Yun Feng, Jingdong Song, Hongning Zhou, Guodong Liang*National Natural Science Foundation of China (81290342 [Special Science Fund]), State Key Laboratory of Infectious Disease Prevention and Control (2014SKLID103)
2016YFD0500300Effects of calcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in miceJanuary, 2017BoxiangGui, Qin Chen, Chuanxia Hu, Caihui Zhu, Guimei He*National Natural Science Foundation of China (31402163), Shanghai Municipal Center for Disease Control & Prevention
2016YFD0500300Intraviral interactome of Chikungunya virus reveals the homo-oligomerization and palmitoylation of structural protein TFApril, 2019Han Yin, Peiqi Yin, Hongjian Zhao, Na Zhang, Xia Jian, Siqi Song, Shan Gao, Leiliang Zhang*National Natural Science Foundation of China (81871663, 81672035), Shandong Provincial Natural Science Foundation (ZR2017PC017).Dr. Andres Merits and Dr. Terence Dermody provided reagents.
2016YFD0500300Retromer localizes to autophagosomes during HCV replicationApril, 2017Peiqi Yin, Zhi Hong, Leiliang Zhang*, YouyangKe*National Natural Science Foundation of China (81471955, 81672035, 81301438), the Program for Changjiang Scholars and Innovative Research Team in Universities (IRT13007), Fundamental Research Funds for the Central Universities (3332016085).GuangboYangcontributed to this research;Charles Rice, Francis Chisari,ZhipingXie, Masanori Ikeda, Nobuyuki Kato and TakajiWakita provided reagents.
2016YFD0500300Sec24C – Dependent Transport of Claudin -1 Regulates Hepatitis C Virus EntryAugust, 2017Peiqi Yin, Ye Li, Leiliang Zhang*National Natural Science Foundation of China (81672035, 81471955), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2016-12M-3-020), Fundamental Research Funds for the Central Universities (3332013118, 2016ZX310047), the Program for Changjiang Scholars and Innovative Research Team in Universities (IRT13007).Charles Rice, Francis Chisari, Xiaowei Chen, Sidney Yu and Ping Zhao provided reagents.
2016YFD0500300Entry of severe fever with thrombocytopenia syndrome virusDecember, 2016Fei Yuan, Aihua Zheng*National Natural Science Foundation of China (L1524009), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB11030800).Wuhan Institute of Virology hosted this research.
2016YFD0500300Development and validation of a novel 13-plex PCR system for commonly used short tandem repeats in horses (Equus caballus)September, 2019S. Shang, M. Zhang, Y. Zhao, W. Dang, P. Hua, S. Zhang*, Z. Wang*The National Key Research and Development Program of China (2016YFC1200100), National Natural Science Foundation of China (31672274,31570382).
2016YFD0500300Molecular signatures and functional analysis of beige adipocytes induced from in vivo intra-abdominal adipocytesJuly, 2018HuilingXue, Zhe Wang, Yongjie Hua, Shanshan Ke, Yao Wang, JunpengZhang,Yi-Hsuan Pan, Wenjie Huang, David M. Irwin, Shuyi Zhang*The National Key Research and Development Program of China (2016YFC1200100), National Natural Science Foundation of China (31672274,31570382).
2016YFD0500300Retention and losses of ultraviolet-sensitive visual pigments in batsAugust, 2018Longfei Li, Hai Chi, Haonan Liu, Yu Xia, David M. Irwin, Shuyi Zhang*, Yang Liu*The National Key Research and Development Program of China (2016YFC1200100), National Natural Science Foundation of China (31601855,31570382).YimengCui,Dr. Rosalie K. Crouch, Dr. Lisa A. Neuhold
2016YFD0500300Synergy between MC1R and ASIP for coat color in horses (Equus caballus)February, 2019Songyang Shang, Yan Yu, Wanyi Dang, Yuxin Zhao, Junpeng Zhang, Xia
Qin, David M. Irwin, Qin Wang, Fei Liu, Zhenshan Wang, Shuyi Zhang*, Zhe Wang*
The National Key Research and Development Program of China (2016YFC1200100), National Natural Science Foundation of China (31672274,31570382).
2016YFD0500300Identification of Bridging Centrality in Complex NetworksJuly, 2019Wei Liu, Matteo Pellegrini, Aiping Wu*National Natural Science Foundation of China (31470213), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2016-12M-1-005), Jiangsu Provincial Natural Science Foundation (BK2016245), Shandong Provincial Natural Science Foundation (ZR2017MF052), Ludong University (LA2016007)
2016YFD0500300Large discrepancy between the two-way rNHT distances in hemagglutinin-inhibition assayAugust, 2016Yousong Peng, Dayan Wang, Yuelong Shu*, Taijiao Jiang*The National Key Research and Development Program of China (2016YFC1200200), National Natural Science Foundation of China (31500126, 31371338), Hunan University Young Faculty Growth Program (31107040720).
2016YFD0500300PREDAV-H1-a user-friendly web server for predicting antigenic variants of influenza H1N1 virusesOctober, 2018Congyu Lu, Mi Liu, Aiping Wu, Yuelong Shu, Yousong Peng*, Taijiao Jiang*The National Key Research and Development Program of China (2016YFC1200200), National Natural Science Foundation of China (31500126, 31671371), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2016-12M-1-005), Fundamental Research Funds for the Central Universities.
2016YFD0500300Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea VirusMarch, 2017Fenghua Wang, Cheng Chen, Kailin Yang, Yang Xu, Xiaomei Liu, Fan Gao, He Liu, Xia Chen, Qi Zhao, Xiang Liu, Yan Cai*, Haitao Yang*China Ministry of Science and Technology National 973 Project Grant (2015CB859800), National Natural Science Foundation of China (31528006), Tianjin Marine Science and Technology Program (KJXH2014-16).
2016YFD0500300The conformational changes of Zika virus methyltransferase upon converting SAM to SAHJanuary, 2017Han Zhou, Fenghua Wang, Haofeng Wang, Cheng Chen, Tianqing Zhang,
Xu Han, Deping Wang, Chen Chen, Chen Wu, Wei Xie, 王泽方, Lei
Zhang, Lanfeng Wang*, Haitao Yang*
China Ministry of Science and Technology National 973 Project Grant (2015CB859800), National Natural Science Foundation of China (31528006), and the start-up funds from Institute Pasteur of Shanghai, Chinese Academy of SciencesInstitute Pasteur of Shanghai was involved in this research.
2016YFD0500300A Novel DT40 Antibody Library for the Generation of Monoclonal AntibodiesJune, 2019Bei Wang, Fei Wang, He Huang*, Zhendong Zhao*The Project of the National Defense Science and Technology Innovation Special Zone (17-163-12-ZT-005-013-01), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2016-12M-1-013, 2016-12M-1-014, 2016-12M-3-020), Fundamental Research Funds for the Central Universities (2018PT31032).This research is directly related to PLA research projects; the copyright was held by Wuhan Institute of Virology.
2016YFD0500300Crystal structure of Middle East respiratory syndrome coronavirus helicaseJune, 2017Wei Hao, Justyna Aleksandra Wojdyla, Rong Zhao, Ruiyun Han, Rajat Das,
Ivan Zlatev, Muthiah Manoharan, Meitian Wang, Sheng Cui*
National Natural Science Foundation of China (81501759, 81572005).Hongjie Zhang (Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences) was involved in this research.
2016YFD0500300Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replicationOctober, 2017Tao Wang, Bei Wang, He Huang, Chongyang Zhang, Yuanmei Zhu, Bin Pei, Chaofei Cheng, Lei Sun, Jianwei Wang, Qi Jin, Zhendong ZhaoNational Natural Science Foundation of China (81572008, 31400159), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2016-12M-1-014), the Innovative Research Team in University (IRT13007)
2016YFD0500300Structural characterization of free-state and product-state Mycobacterium tuberculosis me­thionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanismJune, 2018Wei Wang, Bo Qin, Justyna Aleksandra Wojdyla, Meitian Wang, Xiaopan Gao*, Sheng Cui*National Natural Science Foundation of China (11775308, 81401714), Fundamental Research Funds for the Central Universities (2016ZX310054), China Academy of Chinese Medical Sciences grants (2017PT31049, 2017-12M-3-014), Natural Science Foundation of Beijing Municipality grants (7182117, 77174288).
2016YFD0500300Transduction with Lentiviral Vectors Altered the Expression Profile of Host MicroRNAsJuly, 2018He Huang, Chongyang Zhang, Bei Wang, Fei Wang, Bin Pei, Chaofei Cheng, Wei Yang, Zhendong Zhao*National Natural Science Foundation of China (81301440), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (016-12M-1-013, 2016-12M-1-014), Fundamental Research Funds for the Central Universities (3332014026, 2017PT31010).
2016YFD0500300Differential immune responses of Monochamusalternatus against symbiotic and entomopathogenic fungiJuly, 2017Wei Zhang, Jie Meng, Jing Ning, Peijun Qin, Jiao Zhou, Zhen Zou, Yanhong Wang, Hong Jiang, Faheem Ahmad, Lilin Zhao*, Jianghua Sun*The National Key Research and Development Program of China (2016YFC1200604), The High Technology Research and Development Program (HTRDP) of China (2014AA020529), National Natural Science Foundation of China (31572272, 31370650, 31402013, 31221091, 31672291, L1524009), The Forestry Industry Research Special Funds for Public Welfare Program (201204501), The CAS Key Research Projects of the Frontier Science (QYZDB) (QYZDBSSW-SMC014), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2015-SM-C-02).
2016YFD0500300HA Triggers the Switch from MEK1 SUMOylation to Phosphorylation of the ERK Pathway in Influenza A Virus-Infected Cells and Facilitates Its InfectionFebruary, 2017Chengmin Wang, Huimin Liu, Jing Luo, Lin Chen, Meng Li, Wen Su, Na Zhao, Shelan Liu, Li Xie, Yaxiong Jia, Hua Ding, Xiufeng Wan, Hongxuan He*National major research and development projects (2016YFD0500300), China Agriculture Research System Poultry-related Science and Technology Innovation Team of Peking (CARS-PSTP).China Agriculture Research System Poultry-related Science and Technology Innovation Team of Peking (CARS-PSTP) contributed to this research.
2016YFD0500300Histone Deacetylase 1 Plays an Acetylation-Independent Role in Influenza A Virus ReplicationDecember, 2017Lin Chen, Chengmin Wang, Jing Luo, Wen Su, Meng Li, Na Zhao, WentingLyu, Hamidreza Attaran, Yapeng He, Hua Ding, Hongxuan He*The key study program of the National Natural Science Foundation of China (No. 81101835), the Chinese Academy of Sciences (KSZD-EW-Z-005-001-1), National key plan for Scientific and Development of China  (2016YFD0500300), China Agriculture Research System Poultry-related Science and Technology Innovation Team of Peking (CARS-PSTP)Wanqin Liao, Xiaoling Li, Ting Han, Qingxun Zhang, Zhirong Shen and Lv Lu also contributed to this research.
2016YFD0500300Mcl-1 suppresses abasic site repair following bile acid–induced hepatic cellular DNA damageJuly, 2017Haiyang Yu, Xiaoqing Zhang, Ren Liu, Hui Li, Xiaolong Xiao,
Yuzheng Zhou, Chaoying Wei, Manyi Yang, Mingmei Liao,
Jinfeng Zhao, Zanxian Xia, Qiande Liao
National Natural Science Foundation of China (81272193, 81302075, 81402001, and U1603126), the National Key Research and Development Program of China (2016YFD0500300).
2016YFD0500300Regulation of WNT_β-catenin signaling by carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) in colorectal cancer cellDecember, 2017Chengming Ding, Jun He, Wenyan Liao, Jie Chen, Junhua Li, Gengsheng He, Zeming Jia, Yaoting
Zhang, Jiaxing Luo, Xiaoming Dai, Liming Zhang, Hui Li, Yuzheng Zhou, Ai Lu, Zanxian Xia, Jun Zhao,
Jian Peng
The National Key Research and Development Program of China (2016YFC12- 00200), the National Natural Science Foundation of China (U1603126), Hunan Provincial Natural Science Fund in China (2017JJ2334).Pinghui Feng (University of Southern California), Chengyu Liang (University of Southern California) also contributed to this research
2016YFD0500301Epidemic and molecular characteristic of human adenovirus infection among patients with febrile respiratory syndrome from a hospital in Qinghai Province, 2012-2015July, 2017Hong Li, Gaoshan Liu, Yan Shi, PeihuaNiu, Shuangying Jiang, Lili Xu, Roujian Lu, Shengcang Zhao*, Wenfie Tan*National Infectious Disease Control S&T Grand Project (2013ZX10004-601, 2014ZX10004-001, 2012ZX10004-208).
2016YFD0500301Comparison of viral and epidemiologicalprofiles of hospitalized children with severeacute respiratory infection in Beijing and Shanghai, ChinaAugust, 2018Yanjie Zhao, Roujian Lu, Jun Shen, ZhengdeXie, Gaoshan Liu, Wenjie Tan*The National Key Research and Development Program of China (2016YFC1200200), National Infectious Disease Control S&T Grand Project (2014ZX10004001–002, 2017ZX10104001–002, 2017ZX10104001–003).
2016YFD0500301Humoral and cellular immunity against both ZIKV and poxvirus is elicited by a two-dose regimen using DNA and non-replicating vaccinia virus-based vaccine candidatesMarch, 2019Ying Zhan, Yao Deng Baoying Huang, Qianqian Song, Wen Wang, Yang Yang, Lianpan Dai, WenlingWang, Jinghua Yan, Gorge F Gao, Wenjie Tan*The National Key Research and Development Program of China (2016YFC1200200, 2016YFC1200901), National Infectious Disease Control S&T Grand Project (2016ZX10004001-003).
2016YFD0500301Molecular Evidence of Human Monkeypox Virus Infection, Sierra LeoneJune, 2019Fei Ye, Jingdong Song, Li Zhao, Yi Zhang, Lianxu Xia, Lingwei Zhu, Idrissa Laybohr Kamara, Jiao Ren, Wenling Wang, Houwen Tian, Guizhen Wu, Wenjie TanThe National Key Research and Development Program of China (2016YFC1200200, 2016YFC1200905), National Infectious Disease Control S&T Grand Project (2016ZX10004222-002).
2016YFD0500301Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus–Derived CD8+ T Cell Epitopes and Host MHCNovember, 2016William J Liu, Jiaming Lan, Kefang Liu, Yao Deng, Yanfeng Yao, Shaolian Wu, Hong Chen, Lingling Bao, Haifeng Zhang, Min Zhao, Qihui Wang, Lingxia Han, Yan Chai, Jianxun Qi, Jincun Zhao, Songdong Meng, Chuan Qin, Fu GAO, Wenjie TanChina Ministry of Science and Technology National 973 Project Grant (2015CB910500), National Infectious Disease Control S&T Grand Project (2016ZX10004222-003, 2014ZX10004001-002, 2014ZX10004001-006,
2012ZX10004501-004), National Natural Science Foundation of China (81373141, 81401312,
81461168030), Municipal Healthcare Joint Innovation Major Project of Guangzhou Grant (201604020011)
Bart L. Haagmans and Ron A. M. Fouchier (Erasmus MC, Rotterdam, the Netherlands) for providing MERS-CoV (isolate hCoV-EMC/2012); Stanley Perlman (University of Iowa, Iowa City, IA) for providing the rAd5-hDPP4 stock; Jianfang Zhou (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention) for assistance on the flow cytometry.
2016YFD0500301Safe and Sensitive Antiviral Screening Platform Based on RecombinantHuman Coronavirus OC43 Expressing the Luciferase Reporter GeneJuly, 2016Liang Shen, Yang Yang, Fei Ye, Gaoshan Liu, Marc Desforges, Pierre J Talbot, Wenjie TanNational Infectious Disease Control S&T Grand Project (2014ZX10004001, 2013ZX10004601).
2016YFD0500301Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, ChinaJune, 2019Gao Shan Liu, Hong Li, Sheng Cang Zhao, Rou Jian Lu, Pei Hua Niu*, Wen Jie Tan*The National Key Research and Development Program of China (2016YFC1200200), National Infectious Disease Control S&T Grand Project (2017ZX10104001-002-003, 2014ZX10004001-002).The CDC of Qinghai also contributed to this research.
2016YFD0500301Development and application of novel techniques for viral isolation and cultureMarch, 2017Bing-jie Wu, Rou-jian Lu, Wen-jie Tan*National Natural Science Foundation of China (81100062).
2016YFD0500301Confirmation of one human Monkeypox infection in Sierra Leone in 2017 by molecular and serological detectionJune, 2019Fei Ye, Jing-dong Song, Li Zhao, Yi Zhang, Lian-xu Xia, Ling-wei Zhu, Jiao Ren, Wen-ling Wang, Gui-zhen Wu, Hou-wen Tian*, Wen-jie Tan*National Infectious Disease Control S&T Grand Project (2016ZX10004222-002).
U72016YFD0500301Study on the Cell Biological Properties and Replication Defective Mechanism of Replication-deficient Vaccinia Virus Titan Strain2January 2019ZHAO Ying, HUANG Pan, ZHAO Li, REN Jiao, ZHANG Peng, RUAN Li, TAN Wenjie, TIAN Houwen*
2016YFD0500301Establishment of an ELISA Assay for Serum Antibodies to Monkeypox Virus InfectionDecember 2018REN Jiao, YE Fei, ZHAO Li, GUAN Xixi, ZHAO Ying, SONG Jingdong, TIAN Houwen, TAN Wenjie*
2016YFD0500301Titration and Neutralizing Antibody Detection of Middle East Respiratory Syndrome Coronavirus Infection Based on Avicel-crystalline Violet Staining of Empty SpotsJanuary 2017WANG Wenling, HUANG Baoying, WANG Huijuan, ZHAO Li, LU Roujian, ZHU Na, DENG Yao, TAN Wenjie*National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2016ZX10004001
2016YFD0500301Rapid Establishment of a Mouse Model of MERS-CoVPseudovirus Infection Based on DPP4 TransductionApril 2019NIU Junwei, ZHAN Ying, DENG Yao, TAN Wenjie*National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2016ZX10004001-003
2016YFD0500301New Technology and Preliminary Application of Neutralizing Antibody Detection Based on Rabies Virus CVS-11 PseudovirusOctober 2016DENG Yao, LvXinjun, YU Pengcheng, XU Honglin, TANG Qing, ZHU Wuyang, TAN Wenjie*“863” Program 2014AA021406
2016YFD0500301New Technology and Preliminary Application of Neutralizing Antibody Detection Based on Rabies Virus CVS-11 PseudovirusOctober 2019WANG Wenling, YANG Ren, SONG Qianqian, WANG Huijuan, DENG Yao, ZHAO Li, TAN Wenjie*863 Program 2014AA021406, National Key R&D Program 2016YFC1200900, National Science and Technology Key Projects on Infectious Disease Prevention and Control 2016ZX10004001-003
2016YFD0500301Detection of Zika Virus Antibodies by Luciferase Immunosorbent Assay Based on Zika Virus NS2B Protein-Specific Antigenic PolypeptidesMay 2019WANG Tianyu, WU Wei, DENG Yao, WANG Wenling, TAN Wenjie*, TANG Shixing*National Key R&D Program 2016YFC1200900, National Science and Technology Major Project on Infectious Disease Prevention and Control 2016ZX10004001-003Southern Medical University
2016YFD0500301Enhanced Virulence of Influenza A Virus X31 (H3N2) Mice after Adaptation is Associated with HA and PB2 MutationsNovember 2019LU Funa, WANG Wenling, ZHANG Yawei, TONG Yigang, LIU Kefang, HUANG Baoying, SHEN Xiaoling, TAN Wenjie*National Natural Science Foundation of China 31200127
2016YFD0500301Efficient Screening of Human Coronavirus OC43 Susceptible Cell LinesMay 2017SHEN Liang, ZHU Na, NIU Junwei, HUANG Baoying, LIU Gaoshan, NIU Peihua, TAN Wenjie*National Key R&D Programm 2016YFC1200200, 2016YFC1200905
2016YFD0500301Advances in Human Anellovirus Virus ResearchJanuary 2018LIU Gaoshan, NIU Junwei, TAN Wenjie*
2016YFD0500301Advances in the Antiviral Effects and Mechanisms of Emetine NIU Junwei, TAN Wenjie*
2016YFD0500301Application of Primary Human Airway Epithelial (HAE) Cells for Isolation and Identification of Influenza Virus in Aged Airway SamplesMay 2017ZHU Na, WEI Hejiang, SONG Jingdong, NIU Peihua, WANG Wen, WANG Dayan, SHU Yuelong, TAN Wenjie*National Science and Technology Major Project for Infectious Disease Control 2014ZX10001004-001, 2014ZX10001004-002, National Natural Science Foundation of China 81301430
2016YFD0500301Primary Human Airway Epithelial (HAE) Cell Culture System and its Application in Virology ResearchApril 2017ZHU Na, TAN Wenjie*National Science and Technology Major Project for Infectious Disease Control 2014ZX10001004-001, 2014ZX10001004-002, National Natural Science Foundation of China 81301430
2016YFD0500301Advances in Serological Detection Methods for Zika VirusMay 2019WANG Tianyu, TANG Shixing*, TAN Wenjie*National Key R&D Program 2016YFC1200900, National Major Project on Science and Technology for Infectious Disease Control 2016ZX10004001-003Southern Medical University participated in the study
2016YFD0500301Study on Optimization of Signal Peptide Sequences for Eukaryotic Expression of MERS-CoV Spiked Protein SubunitsJanuary 2019SONG Qianqian, WANG Wenling, ZHAN Ying, LU Funa, DENG Yao, TAN Wenjie*National Key R&D Program 2016YFC1200900, National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2016ZX10004001-003
2016YFD0500302A field‐deployable Insulated Isothermal RT‐PCR Assay for Identification of Influenza A (H7N9) Shows Good Performance in the LaboratorySeptember 2019Ken Inui, Tung Nguyen, Hsin‐Jou Tseng, ChuanFu Mark Tsai, Yun‐Long Tsai, Simon Chung, PawinPadungtod, ZHU Huachen, GUAN Yi,WantaneeKalpravidh, Filip ClaesNational Key R&D Program 2017YFE0190800, USA Agency for International Development EPT-2, NIH HHSN272201400006C, Hong Kong Research Grants Committee Grant RGC-GRF 17118515, 17108417 , 17127714, Shenzhen Peacock Program Grant KQTD201203 National Key R&D Program 2017YFE0190800, USA Agency for International Development Grant EPT-2, NIH Grant HHSN272201400006C, Hong Kong Research Grants Committee Grant RGC-GRF 17118515, 17108417 , 17127714, Shenzhen Peacock Program Grant KQTD201203The Food and Agriculture Organization of the United Nations also contributed to this project
2016YFD0500302Safety and Immunogenicity of an 8 Year Interval Heterologousprime-boost Influenza AH7N7-H7N9 VaccinationApril, 2019Hana M. El Sahly, Robert L. Atmar, Shital M. Patel, Abbie Bellamy, Liwei Liu, Wenshan Hong, ZHU Huachen, GUAN Yi,, Wendy A. Keitel, the DMID 13-0033 Vaccine Study GroupNIH HHSN272201300015I, HHSN272200800002C, hhsn272201500002c, hhsn272201400006c, hongkong Research Grants Committee RGC-GRF 17127714Endy Buchanan, Suzanne Murray, Soju Chang, Valerie Riddle, Teresa Hauguel and Chris Roberts of the National Institutes of Health also contributed to this project.
2016YFD0500302Two Methods for Mapping and Visualizing Associated Data onPhylogenyUsingGgtreeOctober 2018YU Guangchuang, LIN Zanyu, ZHU Huachen, GUAN Yi*National Key R&D Program of China 2017YFE0190800, National Institutes of Health HHSN272201400006C, Shenzhen Peacock Program KQTD201203 National Key R&D Program of China 2017YFE0190800, National Institutes of Health HHSN272201400006C, Shenzhen Peacock Program Grant KQTD201203Jianrong Yang, Sun Yat-sen University, Guanyang Zhang, University of Florida and Chenhao Li, Genome Institute of Singapore contributed to this article
2016YFD0500303Establishment and Preliminary Evaluation of a Method for the Detection of Chikungunya Virus AntigenApril 2017XING Xiaoyue, WU Wei, ZHANG Shuo, ZHANG Quanfu, LI Chuan, LIANG Mi Fang, LI Jiandong, LI Dexin*
2016YFD0500303Acquisition and Expression of Fab Segment Gene of Human-derived Anti-Zika Virus Monoclonal AntibodyDecember 2019YUAN Runyu, SUN Lina, SU Juan, JI Xunmin, LIANG Junhe, CHEN Maoyu, LIANG Mifang*, KE Changwen*National Science and Technology Major Project of China 2018ZX09739002-004, Study on the Pathogenic Spectrum of Viral Infectious Diseases and the Variation Pattern of Viral Gene 2018ZX10713-002, Reform and Development Special Fund of the Ministry of Science and Technology of China 2016273,  Guangdong Provincial Science and Technology Project Funding  for the Prevention and Control of Zika Virus Disease 2016A020250001, Guangdong Medical Science Fund A2018187
2016YFD0500303Single Dose of a rVSV-based Vaccine Elicits Complete Protection against Severe Fever with Thrombocytopenia Syndrome VirusJanuary 2019DONG Fangfang, LI Dandan, WEN Dan, LI Suhua, ZHAO Chaoyue, QI Yue, Rohit K. Jangra, WU Cuiping, XIA Dequan, ZHANG Xing, DENG Fei, Kartik Chandran, ZOU Zhen, YUAN Fei, ZHENG AihuaStrategic Priority Research Program of the Chinese Academy of Sciences XDB11030800, State Key Laboratory of Integrated Pest Management Open Research Program IPM1511, IPM1603WIV led the study. Not all references cited in this paper are included; Qin Chuan, Bao Linlin, Gao Fu, Yan Yan also contributed to this study
2016YFD0500303Identification of Human Biting Midge in the Border Area of China, Laos and Vietnam in Jiangcheng County, Yunnan ProvinceOctober 2019BAI Fang, LI Zhao, YUAN Zhengju, WANG Juan, HE Yuwen, MENG Jinxin, LI Nan, XU Yong, WANG Jinglin*National Natural Science Foundation of China 31460669, 31660714, Yunnan Science and Technology Department Key Fund Project, Yunnan Science and Technology Talents and Platform Plan 2018HB046
2016YFD0500303Development and Application of a qRT-PCR Assay for the Detection of Akabane VirusMar 2019YUAN Zhengju, LIU Wei, LI Nan, MENG Jinxin, HE Yuwen, WANG Jinglin* National Natural Science Foundation of China 31460669, 31660714, Natural Science Foundation of Inner Mongolia 2017MS03382, Yunnan Provincial Science and Technology Department Youth Fund 2014FD075
2016YFD0500303Identification and COI Gene Sequence Analysis of the Non-biting Midge in Hohhot, Inner Mongolia, ChinaFebruary 2019YUAN Zhengju, LIU Wei, LI Nan, MENG Jinxin, HE Yuwen, WANG Jinglin* National Natural Science Foundation of China 31460669, 31660714, Natural Science Foundation of Inner Mongolia 2017MS03382, Yunnan Provincial Science and Technology Department Youth Fund 2014FD075
2016YFD0500303Isolation and Molecular Identification of Gaeta Virus in Biting MidgeOctober 2017DONG Pei, LI Nan, HE Yuwen, XU Tiangang, YIN Jianzhong*, WANG Jinglin*National Natural Science Foundation of China 31460669, Yunnan Provincial Science and Technology Department Youth Fund 2014FD075
2016YFD0500303Morphology and Molecular Biology of Aedes aegypti mosquitoes in Tumertzuo and Alashanzuo Banners, Inner MongoliaApril 2019YUAN Zhengju, LIU Wei, HE Yuwen, MENG Jinxin, LI Nan, WANG Jinglin*National Natural Science Foundation of China 31460669, 31660714, Natural Science Foundation of Inner Mongolia 2017MS03382, Yunnan Provincial Science and Technology Department Youth Fund 2014FD075
2016YFD0500303Morphological and Molecular Biology Identification of Midge/CulicoidesSumatrae Collected in Jiangcheng County, Yunnan ProvinceOctober 2018LI Zhao, FU Qiang, BAI Fang, ZHANG Naxi, XU Yong, YUAN Zhengju, HE Yuwen,WANGJinglin*National Natural Science Foundation of China 31460669, 31660714, Yunnan Provincial Science and Technology Department Youth Fund 2014FD075
2016YFD0500303Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern ChinaDecember 2019SU Qianqian, CHEN Yi, LI Meng, MA Jiajun, WANG Bo, LUO Jing, HE Hongxuan*National Key R&D Program of China 2017YFD0501702, Strategic Priority Research Program of the Chinese Academy of Sciences XDA19050204, Chinese Academy of Sciences CZBZX-1, Beijing Innovation Consortium of Agriculture Research System BAIC04-2019Libiao ZHANG Quansheng LIU, Gaoming LIU also contributed to this project
2016YFD0500303Histone Acetyl Transferase TIP60 Inhibits Thereplication of Influenza A Virus by Activationthe TBK1-IRF3 PathwayNovember 2018MA Guoyao, CHEN Lin, LUO Jing, WANG Bo, WANG Chengmin, LI Meng, HUANG Chengmei, DU Juan, MA Jiajun, Yungfu CHANG, HE Hongxuan*External Cooperation Program of Chinese Academy of Sciences  152111KYSB20150023, Strategic Pioneering Science and Technology Special Project of the Chinese Academy of Sciences XDA19050204, Chinese Academy of Sciences CZBZX-1, Beijing Innovation Consortium of Agriculture Research System BAIC04
2016YFD0500304A Single Residue in the αB Helix of the E Protein is Critical for Zika Virus ThermostabilityJanuary 2018XIE Dongyang, LIU Zhongyu, NIAN Qingkong, ZHU Ling, WANG Nan, DENG Yongqiang, ZHAO Hui, JI Xue, LI Xiaofeng, WANG Xiangxi, SHI Peiyong, QIN Chengfeng*National Science and Technology Major Project of China 2017ZX09101005, 2017ZX10304402 National Natural Science Foundation of China 31770190, U170220023, 81661130162, 81661148054Institute of Biophysics, Chinese Academy of Sciences; Chengfeng Qin – Newton Senior Scholar, British Academy of Medical Sciences, NSF Outstanding Young Scientist 81522025, NSF Innovative Research Group 81621005
2016YFD0500304American Strain of Zika Virus Causes More Severe Microcephaly than an Old Asian Strain in Neonatal MiceOctober 2017ZHANG Feng, WANG Hongjiang, Qin WANG, LIU Zhongyu, YUAN Ling, HUANG Xingyao, LI Guanghui, YE Qing, Haozhen YANG, SHI Lei, DENG Yongqiang, QIN Chengfeng*, XU Zhiheng*National Science and Technology Major Project of China 2017ZX09101005, 2017ZX10304402, National Natural Science Foundation of China 31430037, 31730108, Frontier Science Key Project of Chinese Academy of Sciences QYZDJ-SSWSMC007, Shanghai Brain-Wise Project 16JC1420500, Beijing Human Brain Project Z161100002616004Chengfeng Qin – Newton Senior Fellow, British Medical Association, Weixiang GUO and Xia JIN also contributed to this study
2016YFD0500304Biomimetic Inorganic Camouflage Circumvents Antibody-dependent Enhancement of InfectionOctober 2017Xiaoyu WANG, Yongqiang DENG, Dong YANG, Yun XIAO, Hui ZHAO, Qinggong NIAN, Xurong XU, Xiaofeng LI, Ruikang TANG*, Chengfeng QIN*National Natural Science Foundation of China 81661148054, 81661130162, 21625105, 21571155 Natural Science Foundation of Zhejiang Province LY17B010001 Fundamental Research Funds for the Central Universities 2016QN81020Chengfeng Qin – Newton Senior Scholar, British Academy of Medical Sciences NAF003\1003, NSF Outstanding Young Scientist 81522025, NSF Innovative Research Group 81621005
2016YFD0500304Characterization of the Contemporary Zika Virus in Immunocompetent MiceAugust 2016ZHANG Nana, TIAN Min, DENG Yongqiang, HAO Jiaanan, WANG Hongjiang, HUANG Xingyao, LI Xiaofeng, WANG Yuguang, LING-Zhai ZHAO, ZHANG Fuchun& QIN Chengfeng*State Key Laboratory of Pathogen and Biosafety SKLPBS1601, National Natural Science Foundation of China 81661130162, 31270974, 31470265Chengfeng Qin-Newton Senior Scholar NAF003\1003, NSF Outstanding Young Scientist 81522025, NSF Innovative Research Group 81621005, British Academy of Medical Sciences Chengfeng Qin – Newton Senior Scholar, British Academy of Medical Sciences NAF003\1003, NSF Distinguished Young Scientist 81522025
2016YFD0500304Transfer of Convalescent Serum to Pregnant Mice Prevents Zika Virus Infection and Microcephaly in OffspringDecember 2016WANG Shuo, HONG Shuai, DENG Yongqiang, YE Qing, Ling-Zhai ZHAO, ZHANG Fuchun, QIN Chengfeng*, Xu Zhiheng*973 Program 2014CB942801, 2013DFA31990, 2012YQ03026006, National Natural Science Foundation of China 31430037, 31271156, 81522025, 81621005
2016YFD0500304Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine CandidateSeptember 2018CHEN Qi, WU Jin, YE Qing, MA Feng, Qian ZHU, Yan WU, SHAN Chao, Xuping XIE, Dapei LI, Xiaoyan ZHAN, LI Chunfeng, LI Xiaofeng, Xiaoling QIN, Tongyang ZHAO, WU Haitao, SHI Peiyong, MAN Jianghong, QIN ChengfengNational Science and Technology Major Projectof China 2018ZX09711003, 2017ZX10304402, National Natural Science Foundation of China 31870912, 31770190, U170220023, 81661148054, 81572889, 31522029, 31670883, CAMS Innovation Fund for Medical Sciences  2016-12M-1-005, Beijing Science and Technology Commission Z161100000216154Chengfeng Qin – Newton Senior Scholar, British Academy of Medical Sciences, NSF Innovative Research Group 81621005, NSF Distinguished Youth 81661130162; Peiyong Shi – Awarded STARs from the University of Texas; CDC grant to the University of Texas Western Bay Area Center for Insect-borne Infectious Diseases, Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, UTMB CTSA J. Kleberg Jr. and Helen C. Kleberg Foundation Grant UL1TR-001439, NIH grant AI127744; Jeremy Rich, University of California, San Diego, also contributed to this study
2016YFD0500304Visualization of a neurotropic flavivirus infection in mouse reveals unique viscerotropism controlled by host type I interferon signalingFebruary, 2017LI Xiaofeng, LI Xiaodan, DENG Chenglin, DONG Haolong, Qiu-Yan ZHANG, YE Qing, YE Hanqing, HUANG Xingyao, DENG Yongqiang, ZHANG Bo, QIN Cheng-Feng*National Key R&D Program of China 2016YFD0500400, National Natural Science Foundation of China 81572003, 31300151, 81621005, 31470265Chengfeng Qin – Newton Senior Scholar, British Academy of Medical Sciences NAF003\1003, NSF Innovative Research Group 81621005, NSF Outstanding Young Scientist 81661130162
2016YFD0500304Study on the biological function of glycosylation of Zika virus envelope E protein  December 2018CHENG Mengli, HUANG Xingyao, DENG Yongqiang, LI Xiaofeng, QIN Chengfeng*National Natural Science Foundation of China 81873964
2016YFD0500304Advances in the structure and function of the Zika virus non-structural protein NS5September 2019 HUANG Xingyao, YE Qing, LI Xiaofeng, QIN Chengfeng*           National Natural Science Foundation of China 81522025, 81621005, 8161148054, 31770190
2016YFD0500304Progress in the study of the interaction between Zika virus and type I interferon responseJanuary 2018JI Xue, ZHAO Hui, HUANG Xingyao, LI Xiaofeng, QIN Chengfeng*National Natural Science Foundation of China 81522025, 81621005, 81661148054, 31770190
2016YFD0500304A Peptide-based Viral Inactivator Inhibits Zika Virus Infection in Pregnant Mice and FetusesJuly 2017YU Yufeng, DENG Yongqiang, OUu Peng, WANG Xi, DAI Yanyan, YU Fei, DU Lanying, ZHANG Nana, TIAN Min, Jia-Nan HAO, Yu MENG, Yuan LI, Xiaohui ZHOU, CHEN Fuhe, Yuan Guoyong, QIN Chengfeng, JIANG Shibo& LU Lu863 Program 2015AA020930, National Key R&D Program of China 2016YFC1201000, 2016YFC1200405, 2016YFC1202901, National Natural Science Foundation of China 81630090, 81522025, 81661130162, 81672019The Food and Health Bureau, Hong Kong SAR, and the Department of Health, Hong Kong SAR, also contributed to this study by strengthening the Laboratory for Emerging Infectious Diseases.
2016YFD0500304Long Non‐coding Subgenomic Flavivirus RNAs have Extended 3D Structures and are Flexible in SolutionSeptember 2019ZHANG Yupeng, ZHANG Yikan, LIU Zhongyu, CHENG Mengli, Junfeng MA, Yan WANG, QIN Chengfeng* & FANG Xiangyang*National Key R&D Program of China 2016YFA0500700, National Science and Technology Major Project of China 2018ZX09711003, National Natural Science Foundation of China 81522025, 81621005, 31770190, sponsored by China Young Thousand Talents Program, Tsinghua University Independent Research Program, Beijing Advanced Innovation Center for Structural Biology
2016YFD0500304Near-atomic Structure of Japanese Encephalitis Virus Reveals Critical Determinants of Virulence and StabilityApril 2017Xiangxi WNG, LI Shihua,  ZHU Ling, NIAN Qinggong,  Shuai YUAN, Qiang GAO, Zhongyu HU, YE Qing,
LI Xiaofeng, XIE Dongyang, Neil Shaw, Junzhi WANG, Thomas S. Walter, Juha T. Huiskonen,
Elizabeth E. Fry, QIN Chengfeng, David I. Stuart & RAO Zihe
973 Program 2014CB542800, National Natural Science Foundation of China 31300151, 81330036, 31570717, 81520108019, 81621005, Strategic Priority Research Program of the Chinese Academy of Sciences XDB08020200, UK Medical Research Council G100099, MR / N00065X / 1, Wellcome Trust 090532/Z/07/ZChengfeng Qin – Newton Senior Scholar, British Academy of Medical Sciences, NSF Innovative Research Group 81621005, NSF Outstanding Young Scientist 81661130162; the Oxford Centre for Particle Imaging, UK, also contributed to this research, which was established with funding from the Wellcome Trust (060208/Z/00/Z) and supported by (093305/Z/ 10/Z)
2016YFD0500304Potent Neutralization of Hepatitis A Virus Reveals Areceptor Mimic Mechanism and the Receptorrecognition SiteJanuary 2017WANG Xiangxi, ZHU Ling, DANG Minghao, HU Zhongyu, Qiang GAO, Shuai YUAN, Yao SUN, Bo ZHANG,
Jingshan REN, Abhay Kotecha, Thomas S. Walter, Junzhi WANG, Elizabeth E. Fry, David I. Stuart,
& RAO Zihe
973 Program 2014CB542800, National Natural Science Foundation of China 81330036, 31570717, 81520108019, 81621005, Strategic Priority Research Program of the Chinese Academy of Sciences XDB08020200, Wellcome Trust 090532/Z/07/ZInstitute of Biophysics, Chinese Academy of Sciences, also contributed to this study; Oxford Centre for Particle Imaging, Oxford, UK, also contributed to this study, which was established with funding from the Wellcome Trust (060208/Z/00/Z) and supported by (093305/Z/10/Z)
2016YFD0500304Chloroquine, a FDA-Approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in MiceSeptember 2017LI Chunfeng, ZHU Xingliang, JI Xue, Natalie DENG Yongqiang, TIAN Min,RoghiyhAliyari, Xiangyang ZUO, YUAN Ling, Shabbir Khan Afridi, LI Xiaofeng, Jae U. Jung, Karin Nielsen-Saines,QINXiaofeng⁎, QIN Chengfeng⁎, XU Zhiheng⁎, CHENG Genhong⁎  973 Program 2014CB942801, 2012YQ03026006, the National Science and Technology Major Project for Significant New Drugs Innovation and Development 2015ZX09102023, State Key Laboratory of Pathogen and Biosafety SKLPBS1601, National Natural Science Foundation of China 31670883, 1500145, 31430037, 91542201, 81590765, CAMS Innovation Fund for Medical Sciences 2016-12M-1-005, US National Institutes of Health R01 AI069120, AI056154, AI078389 502, Youth Funds for the Central Universities 332016125), Shanghai Brain-Intelligence Project 16JC1420500, Beijing Human Brain Project Z161100002616004Chengfeng Qin – Newton Senior Scholar, British Academy of Medical Sciences NAF003\1003, NSF Innovative Research Group 81621005, NSF Outstanding Young Scientist 81661130162
2016YFD0500304A study on Host and Restriction Factors for Chikungunya VirusMay 2018YIN Han, ZHANG Leiliang*
2016YFD0500304Human-derived A/Guangdong/Th005/2017 (H7N9)Exhibits Extremely High Replication in the Lungs of Ferrets and is highly Pathogenic in ChickensMay 2019Shuran GONG, Feifei QI, Fengdi LI, Qi Lv, Guanpeng WANG, Shunyi WANG, Jing JIANG, Lin WANG, Linlin BAO*, QIN Chuan*.National Science and Technology Major Project of China 2017ZX10304402-001, CAMS Innovation Fund for Medical Sciences 2016-12M-1-006, 2016-12M-1-014George Fu Gao, Yuhai Bi, Yanfeng Xu and Yanfeng Yao also contributed to this study
2016YFD0500304The battle against SARS and MERS Coronaviruses-Reservoirs and Animal ModelsJuly 2018Shu-ran GONG, BAO Linlin*  National Science and Technology Major Project of China 2017ZX10304402-001-003, CAMS Innovation Fund for Medical Sciences 2016-12M-1-006, 2016-12M-1-014
2016YFD0500305Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope ProteinMay 2019SONG Hao, Zhennan ZHAO, CHAI Yan, Xiyue JIN, LI Changyao, YUAN Fei, Sheng LIU, Zhengrong GAO, WANG Haiyuan, Jian SONG, Leonardo Vazquez, Yanfang ZHANG, TAN Shuguang, Carlos M Morel, YAN Jinghua, SHI Yi, QI Jianxun, GAO Feng*, George Fu Gao*National Science and Technology Major Project of China 2018ZX10101004, 2015ZX09102024, 2018ZX09711003, 2018ZX10733403, National Natural Science Foundation of China 31872745, CAS Strategic Pioneering Science and Technology Special Project XDB29010000, CAS Youth Innovation Promotion Association 2017117, 2015078, the National Science Fund for Distinguished Young Scholars 81622031   Translated with www.DeepL.com/Translator (free version)The Center for Bioimaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, also contributed to this study; Yuanyuan Chen, Bingxue Zhou and Zhenwei Yang, Institute of Biophysics, Chinese Academy of Sciences, also contributed to this study; F. Gao, as Principal Investigator of the Innovative Research Group 81621091 of the National Natural Science and Technology Foundation of China and the External F. Gao also contributed to this study as the Principal Investigator of the NSFC Innovative Research Group 81621091 and the External Collaboration Program 153211KYSB20160001 of the Chinese Academy of Sciences
2016YFD0500305Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus–derived CD8+ T Cell Epitopes and Host MHCNovember 2016LIU Jun, LAN Jiaming, LIU Kefang, DENG Yao, YAO Yanfeng, Shaolian WU, CHEN Hong, BAO Linlin, Haifeng ZHANG, ZHAO Min, Qihui WANG, Lingxia HHAN, CHAI Yan, QI Jianxun, ZHAO Jincun, MENG Songdong, QIN Chuan, George Fu Gao, TAN Wenjie.973 Program 2015CB910500, National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2016ZX10004222-003, 2014ZX10004001-002, 2014ZX10004001-006, 2012ZX10004501-004, National Natural Science Foundation of China 81373141, 81401312, 81461168030, Guangzhou Medical and Health Care Joint Innovation Major Project 201604020011Jianfang Zhou, CDC, Stanley Perlman, University of Iowa, USA, L. Haagmans, Ron A.M. Fouchier, Erasmus MC, Rotterdam, The Netherlands, also contributed to this study; cross-research literature within the project, bringing together multiple teams
2016YFD0500305Structural and Functional Insights into MCR-2 Mediated Colistin ResistanceSeptember 2018Xudong Wang, Qiong Lu, QI Jianxun, CHAI Yan, YouchunWang&GAO Fu      CAS Strategic Pioneering Science and Technology Special Project XDB08020100,External Cooperation Program of Chinese Academy of Sciences 153211KYSB20160001GAO Fu also contributed to this study as the chief researcher of the Innovative Research Group 81621091 of the National Natural Science Foundation of China
2016YFD0500305Structures of Human-infecting ThogotovirusFusogens Support a Common Ancestor with Insect BaculovirusOctober 2017PENG Ruchao, Shuijun ZHANG, Yingzi CUI, SHI Yi, George Fu Gao, QI Jianxun“973” Program 2013CB531502, 2014CB542503, National Science and Technology Major Project of China 2017ZX10303403, CAS Strategic Pioneering Science and Technology Special Project XDPB03, National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 81622031, CAS Youth Innovation Promotion Association 2015078GAO Fu also contributed to this study as the chief researcher of the Innovative Research Group 81621091 of the National Natural Science Foundation of China
2016YFD0500305Structure of the Nsp2 PL2 Domain of the PRRSV Non-structural Protein and its Deubiquitinating Enzyme FunctionJune 2018ZHANG Lei, HONG Wenjiao, ZHANG Lilin, LAI Ruiqiao, SU Yanxin, ZHAO Chengxue, LU Dong, LIU Xianming, HUANG Jinhai*.Tianjin Science and Technology Program Project 16YFZCNC00640, Tianjin Natural Science Foundation 17JCZDJC33900
2016YFD0500306A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoVAugust 2018ZHAO Guangyu, Lei HE, SUN Shihui, QIU Hongjie, TAI Wanbo, Jiawei CHEN, Jiangfan LI, CHEN Yuehong, GUO Yan, Yufei WANG, Jian SHANG, Kaiyuan JI, Ruiwen FAN, DU Enqi, JIANG Shibo ,LI Fang , DU Lanying , ZHOU YusenNational Natural Science Foundation of China 81571983, China Science and Technology Innovation Grant 3407049, SKLPBS1704, State Key Laboratory of Pathogen and Biosafety, NIH Grants R01AI137472, R21AI109094, R21AI128311, R01AI089728, r01ai110700, r01ai139092
2016YFD0500306Bovine Adenovirus Type 3 Virions cannot be Rescued in Vivo after Full-length Viral Genome Transfection in the Absence of Detectable Polypeptide IXJuly 2017Peng ZHANG, Qinghong XUE, Jing MA, Jingjing REN, Shuili XIA, Lu ZHANG, Wenbin WANG, Suresh K. Tikoo*, Enqi DU*  Natural Sciences and Engineering Research Council of Canada, Saskatchewan Health Research Foundation, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Grant No. SKLVBF201405, National Natural Science Foundation of China , Grant No. 31101803/C1803
2016YFD0500306Comparison of Three Commonly Used Fusion Tags for the Expression of Nanobodies in the Cytoplasm of Escherichia ColiJanuary 2018Ze-hui LIU, Di HUANG, Xiangjing FU, Peng CHENG & DU Enqi*.State Key Laboratory of Pathogen and Biosafety Open Research Project SKLPBS1522
2016YFD0500306Melatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum StressDecember 2017Yanhua CUI, Lipeng REN, Bo LI, Jia FANG, Yuanxin ZHAI, Xin HE, DU Enqi, Yiliang MIAO, Jinlian HUA, PENG Sha*.National Key R&D Program 2016YFA0100203, National Natural Science Foundation of China 31572399, 31272518, Key Science and Technology Projects of Shanxi Province 2015NY157
2016YFD0500306Surface Displaying of Swine IgG1 Fc Enhances Baculovirus-vectored Vaccine Efficacy by Facilitating Viral Complement Escape and Mammalian Cell TransductionMay 2017Zehui LIU, Yangkun LIU, Yuanyuan ZHANG, Yajuan YANG, Jingjing REN, Xiaoying ZHANG*, Enqi DU*.State Key Laboratory of Pathogen and Biosafety Open Research Project SKLPBS1522, National Natural Science Foundation of China 31572556, Shaanxi Province Science and Technology International Cooperation Base Key Construction Program 2015SD0018
2016YFD0500307Blockade of the C5a–C5aR Axis Alleviates Lung Damage in hDPP4-transgenic Mice Infected with MERS-CoVApril 2018Yuting JIANG, ZHAO Guangyu, Nianping SONG, LI Pei, CHEN Yuehong, GUO Yan, LI Junfeng, DU Lanying, JIANG Shibo, GUO Renfeng, SUN Shihui*, ZHOU Yusen*.National Key R&D Program 2016YFC1202903, National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2017ZX10304402-003, National Natural Science Foundation of China 81571983, Military Logistics Research Project BWS14J058, 16CXZ039Directly involved in military research projects
2016YFD0500307Cryo-electron Microscopy Structures of the SARS-CoV Spike Glycoprotein Reveal a Prerequisite Conformational State for Receptor BindingDecember 2016Miao DU, Wenfei Song, Haixia Zhou, Jingwei Xu, Silian Chen, Ye XIANG, Xinquan WangNational Key R&D Program of China 2016YFA0501100, National Natural Science Foundation of China 81471929, U1405228, 31470721, 81550001
2016YFD0500307Structural Definition of a Unique Neutralization Epitope on the Receptor-binding Domain of MERSCoV Spike GlycoproteinJuly 2018GUI Miao, SONG Wenfei, ZHOU Haixia, XU Jingwei, CHEN Silian, XIANG Ye, WANG Xinquan*. ZHANG Senyan, ZHOU Panpan, WANG Pengfei, Yangyang LI, Liwei JIANG, Wenxu JIA, Han WANG, Angela FAN, Dongli WANG, SHI Xuanling, FANG Xiangyang, Michal Hammel, Shuying WANG, LI Xiaoyu, CEN ShanNational Key R&D Program of China 2016YFC1200902, National Natural Science Foundation of China 31470751, U1405228, 81530065, 81471929, Bill & Melinda Gates Foundation Grand Challenges Fund Program 81661128042Tan Wenjie, Chinese Center for Disease Control and Prevention, (CCDC), Yin Tianlei&JiangShibo, Hudan University, also contributed to this study; the Bill & Melinda Gates Foundation sponsored the study
2016YFD0500307Structural and Functional Definition of a Vulnerable Site on the Hemagglutinin of Highly Pathogenic Avian Influenza A Virus H5N1February 2019Pengfei WANG, Yanan ZUO, Jianfeng SUN, Teng ZUO, Senyan ZHANG, Shichun GUO, Xuanling SHI, Mifang LIANG, Paul ZHOU, ZHANG Linqi, WANG Xinquan973 Program 2014CB542500, National Science and Technology Major Project of China2018ZX10731101-002, 2017ZX1020110, National Natural Science Foundation of China 31470751, U1405228, 81530065, 8166112804
2016YFD0500307An Integrative Genomic Analysis of Transcriptional Profiles Identifes Characteristic Genes and Patterns in HIV-infected Long-term Non-progressors and Elite ControllersJanuary 2019DING Jiwei, MA Ling, ZHAO Jianyuan, Yongxie LI, ZHOU Jinming, LI Xiaoyu*, CEN Shan*.National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2018ZX10301408, National Natural Science Foundation of China 81772205, 18-I2M-3-004, CAMS Innovation Fund for Medical Sciences 2016-I2M-2-002 XYL and 2017-I2M-1-012 YXZ
2016YFD0500307Association of Gene Polymorphism of SDF1(CXCR12) with Susceptibility to HIV-1 Infection and AIDS Disease Progression-A Meta-analysisFebruary 2018DING Jiwei, ZHAO Jianyuan, ZHOU Jinming, LI Xiaoyu, YANbin WU, GO Mei*, CEN Shan*.National Natural Science Foundation of China 81772205CS , 81361128017, CAMS Innovation Fund for Medical Sciences 2016-12M-2-002
2016YFD0500307Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A VirusJune 2018WANG Jing, WANG Yujia, ZHOU Rui, ZHAO Jianyuan, ZHANG Yongxin, YI Dongrong, LI Quanjie, ZHOU Jinming, GUO Fei, LIANG Chen, LI Xiaoyu, CEN Shan*National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2018ZX10301408, National Natural Science Foundation of China 8150175, Beijing Key Laboratory of Infectious Diseases ProjectThe National Infrastructure for Microbial Resources NIMR-2014-3 provides reagents
2016YFD0500307Human MxB Inhibits the Replication of HCVOctober 2018YI Dongrong, AN Ni, LIU Zhenlong, XU Fengwen, Kavita Raniga, LI Quanjie, ZHOU Rui, WANG Jing, ZHANG Yongxin, ZHOU Jinming, ZHANG Leiliang, AN JING, QIN Chengfeng, GUO Fei, LI Xiaoyu, LIANG Chen*, CEN Shan*.National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases 2018ZX10301408, Canadian Institutes of Health Research HOP-143171 , Canadian Quebec Medical Research Fund International Exchange Program 31711520716 , National Natural Science Foundation of China 81772205, CAMS Innovation Fund for Medical Sciences 2016-I2M-2-002, 2017-I2M-1-012, Youth Fund of Peking Union Medical College Hospital 3332018096, Beijing Key Laboratory of Infectious Diseases ProjectThe National Infrastructure for Microbial Resources NIMR-2014-3 provides reagents
2016YFD0500307MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 proteinFebruary 2019LI Jian, HU Siqi, XU Fengwen, ME Shan, Xiaoman LIU, YIN Lijuan, Fei ZHAO, Xiaoxiao ZHAO, Hong SUN, XIONG Zichen, ZHANG Di, CEN Shan, WANG Jianwei, LIANG Chen*, GUO Fei*.National Natural Science Foundation of China 81601771, 81371808, 81528012, 81702451, 81401673, Canadian Institutes of Health Research CCI-132561, CAMS Innovation Fund for Medical Sciences 2018-12M-3-004, 2016-12M-1-014SHU Yuelong and WANG Dayan of the Chinese Center for Disease Control and Prevention also contributed to this study
2016YFD0500307Development of an anti-Zika virus drug screening model and its applicationFebruary 2019ZHOU Rui, SHI Xing, TIAN Dongfang, ZHANG Yongxin, YU Liyan, MA Xuemei, LI Xiaoyu, CEN Shan*.CAMS Innovation Fund for Medical Sciences 2018-12M-3-004  
2016YFD0500307PKR-dependent cytosolic cGAS foci are necessary forintracellular DNA sensingNovember 2019HU Siqi, Hong SUN, YIN Lijuan, LI Jian, MEI Shan, XU Fengwen, Chao WU, Xiaoman LIU, Fei ZHAO, ZHANG Di, HUANG Yu, REN Lili, CEN Shan, WANG Jianwei, LIANG Chen, GUO Fei*.National Science and Technology Major Project of China 2018ZX10301408-003, 2018ZX10731101-001-018, National Natural Science Foundation of China 81601771, 81371808, 81528012, 81702451, CAMS Innovation Fund for Medical Sciences 2018-12M-3-004, 2016-12M-1-014, Canadian Institutes of Health Research CCI-132561, General Fund of Chinese Academy of Medical Sciences 2019-RC-HL-012, Fundamental Research Funds for Central Universities 333218202

Annex III Index of Source File Information

This table records the location of all news, government materials and other public web information collected during the completion of the report. Important evidence/information is listed separately by its file name and its role is described for information purposes only.

First level informationSecond level informationThird level informationFourth level informationFile nameFile typeDescription
1 Background InformationNews from CCP-affiliated research institutionsChinese Academy of SciencesNA2011 Predecessor Project – “Molecular Mechanisms of Interspecies Infection and Disease Transmission of Important Viruses” Project LaunchedWeb ScreenshotThe earliest research which indicates the CCP has studied the pathogens of human-animal diseases can be traced back to 2005
 Institute of Microbiology, Chinese Academy of Sciences as a Participating Unit Receives the 2017 National Science and Technology Progress Grand PrizeWeb ScreenshotJoint research by several units on H7N9 and other viruses has made a major breakthrough
 Wuhan Institute of Virology held training on confidentiality–Wuhan Institute of Virology, Chinese Academy of SciencesWeb ScreenshotThe work of Wuhan Institute of Virology involves confidentiality
 Wuhan Institute of Virology’s new viral research team was honored as an advanced group of “Women Building Success” by Chinese Academy of SciencesWeb ScreenshotThe earliest research on bat virus at Wuhan Institute of Virology dates back to 2004
FondationMérieuxNAThe conference celebrating the 40th anniversary of reform and opening up. Who are the foreign friends on the podium?Web ScreenshotFrance’s FondationMérieux is a key booster for the CCP in the Sino-French P4 Lab negotiations
 Postdoctoral recruitment in the laboratory of Christopher Méliès at the Institute of Pathogen BiologyWeb ScreenshotThe French Mérieux Foundation’s laboratory assistance at a CCP’s university shows that the interests of the two parties are deeply intertwined
NANA[Keywords] biological resources, non-traditional securityWeb ScreenshotHow to define non-traditional security? Why is there an emphasis on the use of biological resources?
 2016-“Establishment Conference of Bacteriology Group of Medical Microbiology and Immunology Special Committee of Chinese Society of Microbiology” was held in ShanghaiWeb ScreenshotDan Hu of the Military Medical Research Institute of the Nanjing Military Region (known externally as the Eastern Theater Center for Disease Prevention and Control) is a member of it.
 Virology Committee of Chinese Society of MicrobiologyWeb ScreenshotMembers of the CCP Virus Academic Consortium
 The 244th China Engineering Science and Technology Forum – “Joint prevention and control, strict prevention of exotic human-animal disease” was held in BeijingWeb ScreenshotThe CCP People’s Liberation Army, under the name of the Academy of Engineering, its military-led research on human-animal infections was carried out at the same time as the 2016 virus project
 The 2nd International Forum on Influenza and Other Respiratory Viruses was successfully held at the First Hospital of Guangzhou Medical UniversityWeb ScreenshotMalik was present at the event and the session focused on the topic.
Official document issued by the CCP ChinaNANA“AIDS and viral hepatitis and other major infectious diseases prevention and treatment” science and technology major special “Thirteenth Five-Year” general group listDocumentationMembers of the CCP Virus Academic Consortium
 The list of experts for the preparation of the 2018 declaration guide for the “Major Infectious Diseases such as AIDS and Viral Hepatitis” science and technology special projectsDocumentationMembers of the CCP Virus Academic Consortium
 “AIDS and Viral Hepatitis and Other Major Infectious Disease Prevention and Control” science and technology major special projects in the year 2020 video defense evaluation experts listDocumentationMembers of the CCP Virus Academic Consortium
 The third national Human Infectious Pathogenic Microorganisms Laboratory Biosafety Review expert committee listDocumentationMembers of the CCP Virus Academic Consortium
 Compilation instructions of the national science and technology major special budget preparation systemDocumentationIt is possible to decipher the meaning of the numbering of the various research programs of the CCP
The official news release of the CCPHealth Care Commission (formerly Ministry of Health)NANANA(Same content, information output by different institutional ports, evidence retained)
Ministry of Science and Technology National Major ProjectNANANA
NANANA[collation] 2016-2018 “13th Five-Year Plan” major special statisticsDocumentationThe hand-organized collection of project names, lead units and prime movers of the key R&D programs of the CCP China from 2016 to 2018, partial listing of the implementation cycle and project funding
NANANAIntroduction of Infectious Disease Control SpecialWeb ScreenshotThe official introduction of the special infectious disease control
NANANAIntroduction of National Science and Technology Major Special ProjectsWeb ScreenshotThe official web page of the National Science and Technology Major Project explains
First level informationSecond level informationThird level informationFourth level informationFile nameFile typeDescription
2Virus Project Subject InformationNANANA2016 virus project introductionWeb ScreenshotA scientific report article from the Center for Disease Control and Prevention of the CCP China published in Acta Virology in January 2017, detailing the basic information and framework of the project
NANANA[Finish] 2016 virus project detailsDocumentationBasic information, participant information and funding information of the 2016 virus project of the CCP China, manually compiled
0Predecessor program contentNANA2005CB523000 – Study on the mechanism of interspecies infection and transmission of animal-derived virusesDocumentationThe tender for the 2005 virus project led by Gao Fu, complete with a description of its research objectives and course
NANA2011CB504700 – Molecular mechanism of interspecies infection and transmission of important viruses causing diseaseDocumentationThe tender for the 2011 virus project led by Gao Fu, complete with its research objectives and route
2016 Virus Project Literature2016YFD0500300Several(Several, literature on the2016 Virus Project – all)DocumentationResearch results that were involved in the 2016 virus project and published before January 1, 2020 were collected as much as possible based on project information. Corresponding authors’ affiliations were classified in the literature.
2016YFD0500301(Several, literature for topic 1 of the 2016 Virus Project)
2016YFD0500302(Several, literature for topic 2 of the 2016 Virus Project)
2016YFD0500303(Several, literature for topic 3 of the 2016 Virus Project)
2016YFD0500304(Several, literature for topic 4 of the 2016 Virus Project)
2016YFD0500305(Several, literature for topic 5 of the 2016 Virus Project)
2016YFD0500306(Several, literature for topic 6 of the 2016 Virus Project)
2016YFD0500307(Several, literature for topic 7 of the 2016 Virus Project)
Research results of the dead CCP scientistsKey deceased scientistsZhao Zhendong(Several, various papers published by Zhao Zhendong)DocumentationZhao Zhendong, a researcher at the Institute of Pathogenic Biology, Chinese Academy of Medical Sciences, died mysteriously of heart disease in 2020 and can be shown to be a key participant in the 2016 virus project
 Zhao Yongfang(Several, various papers published by Y.F. Zhao)DocumentationZhao Yongfang, a researcher at the Institute of Biophysics of the Chinese Academy of Sciences, died mysteriously in 2016 in a PLA hospital. His unit during his lifetime was a key national research unit in proteinology with outstanding results, and it is believed that the Institute was even created specifically for this person
Additional Important informationWuhan Institute of VirologyNAImportant progress in Middle East respiratory syndrome coronavirus researchWeb ScreenshotTwo fixed-point mutations can infect people across species
NAThe CCP’s infectious disease prevention and control system failsWeb ScreenshotFew domestic P3 laboratories were able to conduct experimental analyses after the COVID-19 outbreak, suggesting that officials are controlling direct contact between the research side and the virus
NACCP researchers are very clear about the ADE effectWeb ScreenshotIt was clear in an interview with Zhou Peng of Wuhan Institute of Virology in 2018 that the ADE effect of the virus is more frightening than the virus itelf
NAWuhan P4 laboratory officially openedWeb ScreenshotSARS outbreak at the end of 2002, the establishment of a P4 lab was proposed to 2003; the Chinese Academy of Sciences Biosecurity Large Science Center is suspected to be a cover nominal unit for conducting military research
NAWuhan Institute of Virology and Wuhan Customs cooperated in the 2019 Military GamesWeb ScreenshotIn 2019, Wuhan Institute of Virology collaborated with Wuhan Customs before the outbreak (followed by a coronavirus exercise on “pneumonia of unknown origin”)
Shantou UniversityNAShantou University 2016 Project TopicsDocumentationSide testimony Guan Yi participated in the 2016 virus project at Shantou University
NAShantou University Li Long’s blog post: To the lost years and graduate careerWeb ScreenshotThe diary of a fellow graduate student, allegedly supervised by Guan Yi, records the work of the Shantou University Virus Research Institute
NAGuan Yi’s team at Shantou University: “Running with viruses, only gold medals and no silver medals”Web ScreenshotThe relationship between Guan Yi and the CoV research topic is further explained: Guan Yi’s team is focused on the infection mechanism; there is collaboration with the Shanghai Pasteur Institute; and the MERS virus samples from the Middle East in the hands of the CCP were obtained by Guan Yi.
NAShantou team wins National Science and Technology Progress Grand Prize for the prevention and control of human H7N9 infectionWeb ScreenshotGuan Yi is also involved in the research project of Shu Yuelong, whose team is focusing on the mechanism of infection
Reported by the CDC Virus Diseases InstituteNA160203 The discovery of Human Novel H7N9 Avian Influenza Virus and Its Pathogenetic Study won the 1st prize of the 2015 China Medical Science and Technology AwardWeb ScreenshotBefore 2015, Shu Yuelong had conducted research on avian influenza in collaboration with the University of Hong Kong, and yielded some results
NA161130 Strengthening Research on Cross-species Infection and Transmission Mechanisms to Enhance Prevention and Control of Major Infectious DiseasesWeb ScreenshotProject kick-off meeting of the 2016 Virus Program. Xia Xianzhu participated; the photos are basically of the project’s various subject leaders; Gao Fu gave an update on the progress of the study, consistent with the analysis of the 2005-2015 virus research predecessor project
NA161216 National Key Research and Development Program “Research on the Occurrence and Dispersal Mechanism of Important Emerging and Emerging Pathogens” Project kick-off meeting held in BeijingWeb ScreenshotOther viral research projects headed by Shu Yuelong in 2016, suspected to be involved in functional protein modification
NA170425 Strengthen the Joint Prevention and Control Mechanism, and Jointly Deal with Exotic Human-Animal DiseasesWeb ScreenshotThe 2016 virus project related meeting attended by the PLA Academy of Military Sciences
NA170727 The first “Hands-on Training Course on Unexplained Pneumonia Surveillance and Human Coronavirus Detection Techniques” was successfully heldWeb ScreenshotTargeted infectious disease detection training in 2017, which also included the detection of avian influenza variants
NA170913 China CDC International Cooperation Department “came to our institute to conduct foreign-related national security education activities”Web ScreenshotIndicates that the CDC has research projects that involve confidentiality
NA171120 The annual promotion meeting of the National Key Research and Development Program “Study on the Cross-Species Infection and Transmission Mechanism of Major Sudden Zoonotic Diseases” and the evaluation meeting of “2017 Vector Biology Development Strategy Research” was successfully heldWeb ScreenshotThere were 22 people in charge of the 7 subjects
NA181030 National Key Research and Development Program “Research on Cross-Species Infection and Transmission Mechanism of Major Outbreak of Human-Animal Infectious Diseases” was successfully held in the mid-term inspection meetingWeb ScreenshotThe mid-term inspection of the 2016 virus project was held at Shantou University, indicating the importance of Shantou University
NA181114 Institute of Viral Diseases successfully held the 2018 National “Hands-on Training Course on Surveillance of Pneumonia of Unknown Cause and Human Coronavirus Detection Techniques”.Web ScreenshotTargeted infectious disease detection training in 2018, which also covers detection of avian influenza variants
NA190920 National Key Research and Development Program “Research on Cross-species Infection and Transmission Mechanism of Major Emerging Human-Veterinary Diseases of Animal Origin” 2018-2019 Project Promotion Meeting was successfully heldWeb ScreenshotThis indicates that the 2016 virus project is winding down and the research is focused on the molecular mechanism of the subject
NA191024 Emergency Technology Center of the Institute of Viral Diseases successfully held the 2019 National Training Course on Research Advances and Detection Techniques for Common and Emerging Respiratory Virus InfectionsWeb ScreenshotThe 2019 training on targeted infectious disease detection also includes the detection of avian influenza variant virus and smallpox monkeypox orthopox virus
Gates FoundationNA2016 NSFC and Bill & Melinda Gates Foundation (BMGF) Grand Challenge Collaborative Research Program Approval NoticeWeb ScreenshotBased on the fact that Lu Lu and Linqi Zhang are also participants in the 2016 Virus Project, it indicates that the Gates Foundation may also be involved in the 2016 Virus Project
NANAIn 2013, the CCP launched the “Search for Virus” programWeb ScreenshotWuhan Institute of Virology began to acquire viruses from all parts of China in 2013
NANAHarbin Veterinary Research Institute Large Animal P4 LaboratoryWeb ScreenshotAccording to AAF’s product case presentation, its partner, the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, has established a large animal biosafety level 4 laboratory
3The Virus Project’s relationship with the University of Hong Kong1Project Funding Record of Malik Peiris / University of Hong KongNANANational Natural Science Foundation of China and Research Grants Council Joint Research Grants Fund 2018-19 List of Funded Research ProjectsWeb ScreenshotIt indicates that Malik of the University of Hong Kong and Jinli Zhao of Guangzhou Medical University collaborated on CoVresearch
2Important Media CoverageNANAMalik received an invitation to the Wuhan Institute of Virology eventWeb ScreenshotIt explains Wuhan Institute of Virology’s intention to cooperate and exchange with Malik
NANAHKU collaborates with the National Respiratory Laboratory under Guangzhou Medical UniversityWeb ScreenshotIt shows that Guangzhou Medical University is one of the channels to establish cooperation between mainland and Hong Kong universities
NANAGoldcorp Medical’s relationship with Guangzhou Medical University and Zhong NanshanWeb ScreenshotGoldfield Medical is essentially a school-run enterprise of Guangzhou Medical University, and the founder of the enterprise has close personal ties with Zhong Nanshan
NANAGoldcorp Medical hires Malik as a consultantWeb ScreenshotMalik
NANAThe capital behind Goldcorp MedicalWeb ScreenshotThe CCP’s Jiang family background behind Goldcorp
3Supported by the CCP & Hong Kong Common FundNANA(Several)DocumentationThe establishment of joint research between Hong Kong and China from the International Cooperation Division of the National Natural Science Foundation of China
4Other InformationVirus Research National Science and Technology Report SummaryNANA(Several)Web ScreenshotFrom the International Science and Technology Reports Search page of the Ministry of Science and Technology of the CCP China, a total of 73 abstracts of virus-related research reports were collected
National Natural Science Foundation RecordsSeveralseveral(Several)Web ScreenshotFrom the results of the project query of the National Natural Science Foundation of China, Collect the fund application status of the relevant figures of the virus plan from 2004 to 2019
Information on other virus researchZika virusNA(Several)Web Screenshot / DocumentationZika virus-related research led by Qin Chengfeng at the Institute of Microbial Epidemiology, Chinese People’s Liberation Army Academy of Military Medical Sciences
Wuhan Institute of Virology researchAnnual Report(Several)DocumentationAnnual reports of laboratory operations for previous years from the Wuhan State Key Laboratory of Virology. The query revealed that two researches of the laboratory were confidential in 2016
Avian influenza virusNA(Several)DocumentationResearch results related to avian influenza published by domestic research institutions of the CCP

Translation: 謐雪兒郭, 许先生, Ranting, 夏星湖

Proofread: DT团队, 文永

Cover photo: 诺亚方舟

Other articles in this series:

Deciphering CCP’s Virus Research Programs – Preamble

Deciphering CCP’s Virus Research Programs – Part 1: the 973 Program

Deciphering CCP’s Virus Research Programs – Part 2: the Disease Control and Prevention Special Program

Deciphering CCP’s Virus Research Programs – Part 3: the Five-Year Plan

Deciphering CCP’s Virus Research Programs – Part 4: the 2016 Virus Program

Deciphering CCP’s Virus Research Programs – Part 5: Details of the 2016 Virus Program

Deciphering CCP’s Virus Research Programs – Part 6: the Hong Kong Connection

Deciphering CCP’s Virus Research Programs – Part 7: Other Related Projects